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肿瘤抑制相关蛋白PHEMX抗体
  • 产品货号：
    BN40371R
  • 中文名称：
    肿瘤抑制相关蛋白PHEMX抗体
  • 英文名称：
    Rabbit anti-ART1 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN40371R-100ul

    100ul

    ¥2360.00

    交叉反应：Human 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40371R-200ul

    200ul

    ¥3490.00

    交叉反应：Human 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

英文名称ART1
中文名称肿瘤抑制相关蛋白PHEMX抗体
别    名ART 1; ART1; FLJ17158; FLJ97586; MGC22455; Pan hematopoietic expression; PHEMX; PHMX; tetraspanin 32; Tetraspanin; tetraspanin32; TSPAN32; TSSC6; Tumor suppressing STF cDNA 6; Tumor suppressing subchromosomal transferable fragment cDNA 6; Tumor suppressing subtransferable candidate 6.   



研究领域肿瘤  细胞生物  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, 
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PHEMX/ART1:101-200/320 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Phemx is a member of the tetraspanin (TM4SF) family of proteins that may be involved in transmembrane signal transduction, regulation of cell proliferation, differentiation and motility. Phemx is a multi-pass membrane protein containing intracellular N- and C-terminal domains, four transmembrane domains and two extracellular loops. It is ubiquitously expressed from early embryogenesis through adulthood. Phemx exhibits predominant expression in hematopoietic tissues suggesting a role in hematopoietic-cell function. In association with the Integrin αIIb/Integrin β3 complex, Phemx functions to stabilize arterial thrombi in platelets and regulate “outside-in” signaling. This interaction may be important in the process of wound healing. The gene encoding Phemx is located in an important tumor-suppressor gene region that has been associated with Beckwith-Wiedemann syndrome as well as a variety of cancers.

Function:
PHEMX belongs to the conserved tetraspanin family of integral membrane proteins, which are thought to form multiprotein networks in the cell membrane in association with multiple protein partners. Tetraspanins have functional roles in cell motility, membrane fusion, proliferation, and adaptive immunity. This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. PHEMX may play a role in malignancies and disease that involve this region as well as hematopoietic cell function. There are 5 isoforms produced by alternative splicing.

Subcellular Location:
Membrane; Multi-pass membrane protein

Tissue Specificity:
Expressed ubiquitously at low levels. High levels of expression are confined to hematopoietic tissues including peripheral blood leukocytes, thymus and spleen.

Similarity:
Belongs to the tetraspanin (TM4SF) family.

SWISS:
P52961

Gene ID:
417

Database links:

Entrez Gene: 417 Human

Omim: 601625 Human

SwissProt: P52961 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















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