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液泡蛋白分选受体SORCS2抗体
  • 产品货号：
    BN40340R
  • 中文名称：
    液泡蛋白分选受体SORCS2抗体
  • 英文名称：
    Rabbit anti-SORCS2 Polyclonal antibody

  • 货号

    产品规格

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  • BN40340R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40340R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称SORCS2
中文名称液泡蛋白分选受体SORCS2抗体
别    名KIAA1329; SORCS 2; Sortilin related VPS10 domain containing receptor 2; VPS10 domain receptor protein; VPS10 domain receptor protein SORCS 2; SORC2_HUMAN.  
研究领域细胞生物  神经生物学  细胞膜受体  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量123kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human SORCS2:201-300/1159 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍There are three SorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, SorCS1, SorCS2 and SorCS3 genes are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS2 (sortilin-related VPS10 domain containing receptor 2) is a 1,150 amino acid single-pass type I membrane protein that is highly expressed in brain and kidney. Containing six BNR repeats and a single PKD domain, SorCS2 is encoded by a gene that maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.

Function:
SORCS2 is a member of the vacuolar protein sorting 10 (VPS10) domain containing receptor protein family. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. These proteins are strongly expressed in the central nervous system.

Subcellular Location:
Membrane; Single pass type I membrane protein.

Tissue Specificity:
Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, skeletal muscle and thymus.

Similarity:
Belongs to the VPS10-related sortilin family. SORCS subfamily.
Contains 6 BNR repeats.
Contains 1 PKD domain.

SWISS:
Q96PQ0

Gene ID:
57537

Database links:
UniProtKB/Swiss-Prot: Q96PQ0.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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