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BN40331R-100ul
100ul
¥2360.00
交叉反应：nan(predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,ELISA
BN40331R-200ul
200ul
¥3490.00
交叉反应：nan(predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,ELISA
| 英文名称 | Chordin |
| 中文名称 | 原肠胚双向形成相关蛋白抗体 |
| 别 名 | Chordin; Chrd; CHRD_HUMAN; MGC133038; Shortgastrulation protein; SOG. |
| 研究领域 | 细胞生物 发育生物学 神经生物学 干细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 99kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Chordin:412-490/951 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The patterning of the CNS relies on the interaction of multiple signaling molecules such as Sonic Hedgehog, Wnts, and BMPs and their antagonists Chordin and Noggin. At midgastrula, expression of Noggin overlaps that of Chordin. Chordin is a key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The gene which encodeschordin maps to human chromosome 3q27. Noggin is a secreted protein that binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily of signaling proteins, such as BMP-2,4,7. The gene which encodes noggin maps to human chromosome 17q22. Function: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. Subunit: Interacts with TWSG1 and/or BMP4 Subcellular Location: Secreted. Tissue Specificity: Expressed at the highest level in liver. Post-translational modifications: Cleaved by tolloid proteases; cleavage participates to dorsoventral patterning during early development. Similarity: Belongs to the chordin family. Contains 4 CHRD domains. Contains 4 VWFC domains. SWISS: Q9H2X0 Gene ID: 8646 Database links: Entrez Gene: 8646 Human Entrez Gene: 12667 Mouse Omim: 603475 Human SwissProt: Q9H2X0 Human SwissProt: Q9Z0E2 Mouse Unigene: 166186 Human Unigene: 20457 Mouse Unigene: 29459 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
