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磷脂酰肌醇结合网格蛋白组装蛋白抗体
  • 产品货号：
    BN40323R
  • 中文名称：
    磷脂酰肌醇结合网格蛋白组装蛋白抗体
  • 英文名称：
    Rabbit anti-PICALM Polyclonal antibody

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    产品规格

    售价

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  • BN40323R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Cow,Horse,Zebrafish,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40323R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Cow,Horse,Zebrafish,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称PICALM
中文名称磷脂酰肌醇结合网格蛋白组装蛋白抗体
别    名CALM; Clathrin assembly lymphoid myeloid leukemia; Clathrin assembly lymphoid myeloid leukemia protein; CLTH; LAP; Phosphatidylinositol-binding clathrin assembly protein; PICAL_HUMAN; PICALM.  
研究领域神经生物学  信号转导  Alzheimer's  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Dog, Cow, Horse, Zebrafish, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量71kDa
细胞定位细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PICALM/CALM:251-350/652 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Function:
Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.

Subunit:
Binds clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate.

Subcellular Location:
Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Colocalized with clathrin in the Golgi area.

Tissue Specificity:
Expressed in all tissues examined.

DISEASE:
Note=A chromosomal aberration involving PICALM is found in diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with MLLT10.

Similarity:
Contains 1 ENTH (epsin N-terminal homology) domain.

SWISS:
Q13492

Gene ID:
8301

Database links:

Entrez Gene: 8301 Human

Entrez Gene: 233489 Mouse

Entrez Gene: 89816 Rat

Omim: 603025 Human

SwissProt: Q13492 Human

SwissProt: Q7M6Y3 Mouse

SwissProt: O55012 Rat

Unigene: 163893 Human

Unigene: 235175 Mouse

Unigene: 24871 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.



















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