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生长激素释放激素同源盒蛋白1抗体
  • 产品货号：
    BN40318R
  • 中文名称：
    生长激素释放激素同源盒蛋白1抗体
  • 英文名称：
    Rabbit anti-Gsh1 Polyclonal antibody

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    产品规格

    售价

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  • BN40318R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse(predicted:Human,Rat,Dog,Pig,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40318R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse(predicted:Human,Rat,Dog,Pig,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称Gsh1
中文名称生长激素释放激素同源盒蛋白1抗体
别    名GS homeo box protein 1; GS homeobox 1; GSH1; GSX1; GSX1_HUMAN; Homeobox protein GSH-1 ; Homeobox protein Gsh1.  
研究领域细胞生物  神经生物学  信号转导  干细胞  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Human, Rat, Dog, Pig, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Gsh1:165-264/264 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Growth hormone-releasing hormone (GHRH) stimulates secretion and synthesis of growth hormone (GH), causes somatotroph proliferation and may have direct actions in fetal/placental development, reproduction and immune function. It exerts its action through high-affinity GHRH receptors present in the anterior pituitary. GSH-1 (GS homeobox 1) is a 264 amino acid hypothalamic nuclear protein that functions as a transcription factor responsible for maintaining GHRH expression as well as playing an important role in pituitary development. Coexpression of CBP leads to significantly enhanced GSH-1-induced GHRH expression, which suggest that CBP may function as a co-activator. Knockdown of GSH-1 mRNA in mice causes a dwarf phenotype, which suggests that certain cases of familial dwarfism may be caused by a mutation of the GSH-1 gene.

Function:
Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

SWISS:
Q9H4S2

Gene ID:
219409

Database links:

Entrez Gene: 219409 Human

Entrez Gene: 14842 Mouse

Entrez Gene: 288457 Rat

SwissProt: Q9H4S2 Human

SwissProt: P31315 Mouse

Unigene: 351785 Human

Unigene: 4797 Mouse




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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