首页>>蛋白研究>>抗体>>钙调神经磷酸酶调节蛋白3抗体（唐氏综合征候选区域蛋白1样蛋白3）
钙调神经磷酸酶调节蛋白3抗体（唐氏综合征候选区域蛋白1样蛋白3）
  • 产品货号：
    BN40310R
  • 中文名称：
    钙调神经磷酸酶调节蛋白3抗体（唐氏综合征候选区域蛋白1样蛋白3）
  • 英文名称：
    Rabbit anti-Calcipressin 3 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN40310R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40310R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称Calcipressin 3
中文名称钙调神经磷酸酶调节蛋白3抗体（唐氏综合征候选区域蛋白1样蛋白3）
别    名Calcipressin-3; Down syndrome candidate region 1 like 2; regulator of calcineurin 3; Down syndrome candidate region 1 like protein 2; Down syndrome candidate region 1-like protein 2; Down syndrome critical region gene 1 like 2; DSCR1L2; hRCN3; MCIP3; Myocyte enriched calcineurin interacting protein 3; Myocyte-enriched calcineurin-interacting protein 3; RCAN family member 3; RCAN3; RCAN3_HUMAN; RCN3; RCN3; MCIP3; Regulator of calcineurin 3.  
研究领域细胞生物  神经生物学  信号转导  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
细胞定位细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Calcipressin 3:151-241/241 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Calcineurin is a Ca(2+) dependent protein phosphatase that is involed in several neuornal functions. Proteins belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFATs (Nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. Calcipressin-2, also known as RCAN2 and DSCR1L1 (Down syndrome candidate region 1-like 1), is a 197 amino acid protein that is highly expressed in both the cytoplasm and nucleus of neurons and is the only RCAN family member that is found in glial cells. Calcipressin-3, also known as RCAN3 and DSCR1L2 (Down syndrome candidate region 1-like protein 2), is a 241 amino acid protein that potentially is involved in central nervous system development. Calcipressin-3 interacts with cardiac troponin I, suggesting that it may play a role in cardiac contraction events.

Function:
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

Tissue Specificity:
Highest expression in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Lower expression in all other tissues.

Similarity:
Belongs to the RCAN family.

SWISS:
Q9UKA8

Gene ID:
11123

Database links:

Entrez Gene: 11123 Human

Entrez Gene: 53902 Mouse

Omim: 605860 Human

SwissProt: Q9UKA8 Human

SwissProt: Q9JKK0 Mouse

Unigene: 656799 Human

Unigene: 331970 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications















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