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BN40309R-100ul
100ul
¥2360.00
交叉反应：Human(predicted:Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN40309R-200ul
200ul
¥3490.00
交叉反应：Human(predicted:Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
| 英文名称 | LAR |
| 中文名称 | 受体蛋白酪氨酸磷酸酶F抗体 |
| 别 名 | LAR; LAR protein; LARFN5C; PTPRF; LARS; LCA homolog; Leukocyte antigen related (LAR) PTP receptor; Leukocyte antigen related; Leukocyte antigen related PTP receptor; Leukocyte antigen related tyrosine phosphatase; Leukocyte common antigen related; Protein Tyrosine Phosphatase Receptor Type F; Protein tyrosine phosphatase receptor type F polypeptide; Ptprf; PTPRF protein; PTPRF_HUMAN; Receptor linked protein tyrosine phosphatase LAR; Receptor type tyrosine protein phosphatase F; Receptor type tyrosine protein phosphatase F precursor; Receptor-type tyrosine-protein phosphatase F. |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, (predicted: Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, ) |
| 产品应用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 210kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PTPRF:30-100/1907 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] Function: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Subunit: Interacts with GRIP1. Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. Contains 8 fibronectin type-III domains. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 tyrosine-protein phosphatase domains. SWISS: P10586 Gene ID: 5792 Database links: Entrez Gene: 5792 Human Entrez Gene: 19268 Mouse Omim: 179590 Human SwissProt: P10586 Human SwissProt: Q5T021 Human SwissProt: Q5T022 Human SwissProt: Q86WS0 Human SwissProt: A2A8L5 Mouse SwissProt: Q9EQ17 Mouse Unigene: 272062 Human Unigene: 29855 Mouse Unigene: 11386 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
