首页>>蛋白研究>>抗体>>锌指蛋白318抗体
锌指蛋白318抗体
  • 产品货号：
    BN40303R
  • 中文名称：
    锌指蛋白318抗体
  • 英文名称：
    Rabbit anti-ZNF318 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN40303R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40303R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称ZNF318
中文名称锌指蛋白318抗体
别    名Endocrine Regulatory Protein; HGNC13578; HRIHFB2436; ZFP318; Zinc Finger Protein 318; ZN318_HUMAN.  
研究领域细胞生物  神经生物学  信号转导  内分泌病  锌指蛋白  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,  (predicted: Dog, Pig, Horse, Rabbit, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量251kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ZNF318:1077-1125/2279 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍ZNF318 is a 2279 amino acid endocrine regulatory protein that localizes to the nucleus. Highly expressed in testis, ovaries and kidneys, ZNF318 is a co-repressor of androgen receptor (AR)-mediated transcriptional activation and is thought to regulate transcription during spermatogenesis. ZNF318 interacts with the N-terminal domain of AR and contains two matrin-type zinc fingers. Two isoforms of ZNF318, designated TZF and TZF-L, are produced due to alternative splicing events. Each of these splice variants are thought to have unique roles in transcriptional regulation. While the TZF isoform functions as a repressor of AR-mediated transcriptional activation, the TZF-L isoform is thought to enhance AR-mediated transcriptional activation.

Function:
ZNF318 encodes a nuclear protein with a zinc finger motif of the Cys2-His2 type that is a novel corepressor of androgen receptor.

Subunit:
Interacts with the N-terminal domain of AR.

Subcellular Location:
Nuclear.

Tissue Specificity:
Expressed in endocrine tissue.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 2 matrin-type zinc fingers.

SWISS:
Q5VUA4

Gene ID:
24149

Database links:

Entrez Gene: 24149 Human

SwissProt: Q5VUA4 Human

SwissProt: Q99PP2 Mouse

Unigene: 509718 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

image.png

image.png