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N-乙基顺丁烯二酰亚胺敏感融合蛋白抗体
  • 产品货号：
    BN40293R
  • 中文名称：
    N-乙基顺丁烯二酰亚胺敏感融合蛋白抗体
  • 英文名称：
    Rabbit anti-NSF Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN40293R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40293R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称NSF
中文名称N-乙基顺丁烯二酰亚胺敏感融合蛋白抗体
别    名N ethylmaleimide sensitive factor; N ethylmaleimide sensitive factor; N ethylmaleimide sensitive factor like protein; N ethylmaleimide sensitive fusion protein; N ethylmaleimide sensitive fusion protein; N-ethylmaleimide-sensitive fusion protein; NEM sensitive fusion protein; NEM sensitive fusion protein; NEM-sensitive fusion protein; NSF; NSF_HUMAN; SKD 2; SKD2; SKD2; Vesicle fusing ATPase; Vesicle fusing ATPase; Vesicle-fusing ATPase; Vesicular fusion protein NSF; Vesicular fusion protein NSF; Vesicular-fusion protein NSF.  
研究领域肿瘤  神经生物学  信号转导  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量83kDa
细胞定位细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human NSF:151-250/744 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Several protein-protein interactions are essential to membrane fusion during endocytosis. Membrane fusion requires interaction among SNARE1 proteins associated with both donor and acceptor membranes (1,2). Following membrane fusion, the α-SNAP cytoplasmic adapter protein binds to the SNARE complex. N-ethylmaleimide-sensitive factor (NSF), a hexameric ATPase, then associates with the α-SNAP/SNARE complex to mediate SNARE disassembly during membrane fusion (3,4). The ATPase activity of NSF induces a conformational change in the α-SNAP/SNARE complex that leads to its dissociation from the membrane, membrane fusion and eventual recycling of the SNARE complex for subsequent membrane fusion (3,4).

Function:
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

Subunit:
Homohexamer. Interacts with GABARAP and GABARAPL2. Interacts with GRIA2. Interacts with PLK2, leading to disrupt the interaction with GRIA2. Interacts with MUSK; may regulate MUSK endocytosis and activity (By similarity). Interacts with CDK16 (By similarity).

Subcellular Location:
Cytoplasm.

Post-translational modifications:
Phosphorylation at Ser-569 interferes with homohexamerization (By similarity).

Similarity:
Belongs to the AAA ATPase family.

SWISS:
P46459

Gene ID:
4905

Database links:

Entrez Gene: 4905 Human

Entrez Gene: 18195 Mouse

Entrez Gene: 60355 Rat

Omim: 601633 Human

SwissProt: P46459 Human

SwissProt: P46460 Mouse

SwissProt: Q9QUL6 Rat

Unigene: 431279 Human

Unigene: 260117 Mouse

Unigene: 13345 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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