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层粘蛋白α4抗体
  • 产品货号：
    BN40282R
  • 中文名称：
    层粘蛋白α4抗体
  • 英文名称：
    Rabbit anti-Laminin alpha 4 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN40282R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40282R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

英文名称Laminin alpha 4
中文名称层粘蛋白α4抗体
别    名LAMA3; LAMA4 1; LAMA4; LAMA4_HUMAN; Laminin alpha 4; Laminin alpha 4 chain; Laminin subunit alpha 4 precursor; Laminin subunit alpha-4; Laminin-14 subunit alpha; Laminin-8 subunit alpha; Laminin-9 subunit alpha; Lamininα4; Laminin α4; Laminin-α4; Laminin α 4.  
研究领域肿瘤  神经生物学  信号转导  细胞粘附分子  细胞外基质  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量200kDa
细胞定位细胞膜 细胞外基质 分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Laminin alpha 4:901-1000/1823 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Laminins are essential and abundant structural non-collagenous glyco- proteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of laminins with stabilizing Type IV collagen networks, Nidogen, and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve, and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression, and tissue architecture. Each laminin is a heterotrimer of a, b, and g chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and cognate laminin receptors. The human Laminin a-4 gene maps to chromosome 6q21 and is expressed in adult heart, lung, ovary, small and large intestines, liver, and placenta.

Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Subunit:
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-4 is a subunit of laminin-8 (laminin-411), laminin-9 (laminin-421) and laminin-14 (laminin-423).

Subcellular Location:
Secreted > extracellular space > extracellular matrix > basement membrane. Major component.

Tissue Specificity:
In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle and dermis.

Similarity:
Contains 4 laminin EGF-like domains.
Contains 5 laminin G-like domains.

SWISS:
Q16363

Gene ID:
3910

Database links:

Entrez Gene: 3910 Human

Entrez Gene: 16775 Mouse

SwissProt: Q16363 Human

SwissProt: P97927 Mouse




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.























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