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卵黄状黄斑病蛋白4抗体
  • 产品货号：
    BN40279R
  • 中文名称：
    卵黄状黄斑病蛋白4抗体
  • 英文名称：
    Rabbit anti-Bestrophin 4 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN40279R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40279R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称Bestrophin 4
中文名称卵黄状黄斑病蛋白4抗体
别    名BEST 4; BEST4; BEST-4; Bestrophin 4; Bestrophin4; Bestrophin-4; Vitelliform macular dystrophy 2 like 2; Vitelliform macular dystrophy 2 like protein 2; VMD2L2; BEST4_HUMAN.  
研究领域肿瘤  信号转导  通道蛋白  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Bestrophin 4:151-250/473 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Bestrophin-4 is a 473 amino acid member of the Bestrophin family of proteins. Members of the Bestrophin family are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (Arg-Phe-Pro) motif and they function as anion channels. Bestrophin-4 acts as a calcium-sensitive chloride channel located in the cell membrane. It is believed that Bestrophin-4 also acts as a channel for other physiologically significant anions, such as bicarbonate. Bestrophin-4 is predominantly expressed in the colon, but can be found at low levels in testis, placenta, trachea, spinal chord, lung and retina.

Function:
Forms calcium-sensitive chloride channels. Permeable to bicarbonate.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung, trachea, testis and placenta.

Similarity:
Belongs to the bestrophin family.

SWISS:
Q9C0D5

Gene ID:
266675

Database links:

Entrez Gene: 510542 Cow

Entrez Gene: 482521 Dog

Entrez Gene: 100052813 Horse

Entrez Gene: 266675 Human

Entrez Gene: 100345949 Rabbit

Entrez Gene: 689103 Rat

Omim: 607336 Human

SwissProt: Q8NFU0 Human

Unigene: 302513 Human

Unigene: 84672 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.













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