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活性依赖的神经保护肽抗体
  • 产品货号：
    BN40204R
  • 中文名称：
    活性依赖的神经保护肽抗体
  • 英文名称：
    Rabbit anti-ADNP Polyclonal antibody

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    产品规格

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  • BN40204R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Cow) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN40204R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Cow) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

英文名称ADNP
中文名称活性依赖的神经保护肽抗体
别    名Activity dependent neuroprotective protein; Activity dependent neuroprotector; NAP; KIAA0784  


研究领域细胞生物  神经生物学  细胞凋亡  转录调节因子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Chicken, Dog, Cow, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量114kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ADNP:331-400/1102 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The activity dependent neuroprotective protein (ADNP) gene is frequently amplified in many neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. ADNP mRNA is abundantly expressed in distinct normal tissues, and high expression levels were encountered in malignant cells. ADNP is implicated in maintaining cell survival, perhaps through modulation of p53. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor.

Function:
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

Subcellular Location:
Nucleus (Potential).

Tissue Specificity:
Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues.

Similarity:
Contains 9 C2H2-type zinc fingers.
Contains 1 homeobox DNA-binding domain.

SWISS:
Q9H2P0

Gene ID:
23394

Database links:

Entrez Gene: 23394 Human

Omim: 611386 Human

SwissProt: Q9H2P0 Human

Unigene: 570355 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

是一个潜在的转录调节因子，参与正常细胞与肿瘤细胞的增殖调控。
广泛分布于大脑、小脑等组织，在肺、肾、小肠以及睾丸等组织也有微弱的表达。对体外培养的glia缺失神经元细胞有保护作用.















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